Likewise, clonidine lauriad mucoadhesive buccal tablets (Clonidine Lauriad®) administration has been found to reduce the percentage of HNC patients developing high-grade mucositis (45.3% clonidine + CRT arm vs. 60% placebo + CRT arm), through the direct inhibition of NF-κB activity and of the downstream pro-inflammatory cytokines-mediated signal [85]. The gene discussed is NFKB1; the disease is mucositis.