In addition to the classic pro-inflammatory cytokines mentioned above, Pingping Li et al. found that the inflammatory mediator galectin-3 (gal-3), which is mainly secreted by M1-like macrophages in visceral adipose tissues, can inhibits the downstream signaling of the insulin receptor (IR) by directly binding with IR, leading to systemic insulin resistance [11–13]. The gene discussed is INSR; the disease is Insulin resistance.