Thus, lncRNA LINC00115 identified as an optimum prognostic signature DERs in our study, may highly correlated with COAD recurrence via functioning as a ceRNA by interacting with hsa-miR-4709 to regulate expressions of SIX4, GRAP, NKAIN4, MMAA, and ERVMER34–1. This evidence concerns the gene SIX4 and colon adenocarcinoma.