In a syngeneic murine model of ovarian cancer, activation of canonical NF-κB signaling specifically in macrophages was sufficient to induce anti-tumor effects, including modulation of macrophages to anti-tumor phenotypes, production of the pro-inflammatory cytokine CXCL9, and infiltration of cytotoxic T cells. The gene discussed is NFKB1; the disease is ovarian carcinoma.