In addition, the comparative analysis of human UCHL1 structure with all five PD-causing mutant versions (except E7A) revealed another commonly deviated region at C-terminal comprises of protein segment 220–223 within farnesylation site (Fig. 4 and Table 3; Additional file 1: Figure S2 and Figure S3; Additional file 2: Table S3 and Table S4). This evidence concerns the gene UCHL1 and Parkinson disease.