We have presented new loci of differential DNA methylation in genes that were previously found to be associated with dyslipidemia (ABCG1, CPT1A, FASN, KLF14, LDLR, LPL, LRP1, PCSK9, PPARG and SREBF1) (Mittelstraß and Waldenberger 2018; Pfeiffer et al. 2015; Rohde et al. 2019; Campanella et al. 2018) but also in new candidate genes, potentially related to hypercholesterolemia. This evidence concerns the gene PCSK9 and metabolic syndrome.