LIPA and familial hypercholesterolemia: Interestingly, the affected pathways in the group of obese with hypercholesterolemia included (1) lipoprotein remodeling in plasma (with hypomethylated promoter of LPL and hypermethylated ABCG1 and ABCA5); (2) regulation of cholesterol storage (with hypomethylated promoters of LPL and PPARG, and hypermethylated ABCG1 and NR1H2); and (3) cholesterol transport (with hypomethylated promoter of LIPA and hypermethylated ABCA5, ABCG1 and ABCG4—responsible for cholesterol efflux) (Table 3a).