ROS1 and cancer: Interestingly, entrectinib (Genentech/Roche) simultaneously targets c-ROS oncogene 1 (ROS1), ALK (anaplastic lymphoma kinase) RTKs, and tropomyosin receptor kinase proteins encoded by neurotrophic tyrosine receptor kinase (NTRK) genes; it was approved as a biomarker-based treatment for ROS1-positive and NTRK fusion-positive cancer.