As with the IRE1-XBP1 pathway, which is a key pathway in MM biology, we hypothesized that, through the inhibition of one of the three branches of UPR, cells are in a process of adaptation to the changes that might occur by the suppression of PERK-related genes, activating other branches of the UPR by the positive or negative regulation of UPR-related genes. Here, ERN1 is linked to Miyoshi myopathy.