SMOX and cystic fibrosis: A recent clinical study in Ireland on cystic fibrosis P. aeruginosa clinical isolates with the same laboratory reference strains (ATCC 27853 and PAO1) showed that tobramycin (aminoglycoside) and ceftazidime (cephalosporin) was the only effective combination to show positive synergism (FIC ≤ 0.5) against a mature biofilm of a single clinical isolate at a concentration of 64 mg/L [41].