Figure 2 illustrates a possible pathway through which EGCG exerts its anti-cancer actions via an anti-oxidant activity on the basis of present and previous findings and discussions [2,22,26,34,37,38,42,43,44]. Modulation of 5′-AMP activated protein kinase (AMPK) by tumor necrosis factor-α (TNF-α) is incorporated into Figure 2 based on the finding by Steinberg et al. [45] that TNF-α suppresses AMPK activity via transcriptional upregulation of protein phosphatase-2C, although this link remains to be explored in experiments using EGCG. This evidence concerns the gene TNF and cancer.