CCN2 and Hepatic fibrosis: The results of a study, in which hepatic stellate LX2 cells and CCl4-induced liver fibrosis model rats are used, indicated that CGA inhibited the mRNA expression of miR-21, Smad7, connective tissue growth factor, α-smooth muscle actin, tissue inhibitor of metalloproteinase 1, MMP-9, and transforming growth factor-β1 (TGF-β1), suggesting that CGA relieves liver fibrosis through the miR-21-regulated TGF-β1/Smad7 signaling pathway [136].