MTOR and cancer: Since ROS generation induced by EGCG can upregulate AMPK, presumably through upregulation of Ca2+/calmodulin-dependent protein kinase kinase (CaMKK) and/or liver kinase B1 (LKB1) [49,50], leading to downregulation of mechanistic target of rapamycin kinase (mTOR) which results in anti-cancer effects.