Therefore, the present study aimed to investigate the effect among Jordanian DM2 patients of major genetic variants HMGCR rs17244841, APOE rs7412 and rs429357, and SLCO1B1 rs2306283 and rs11045818 on the atorvastatin response, which is the most commonly used statin at the University of Jordan Hospital. Here, HMGCR is linked to myotonic dystrophy type 2.