However, the risk of developing EC in patients with LS by the age of 70 ranges from 14% to 71% and is dependent on a mutation in a particular gene-approximately 14–54% for patients with MLH1/MSH2 mutations, 17–71% for patients with a mutation in MSH6 and 15% in for instances of PMS2 [13]. This evidence concerns the gene MSH2 and Leigh syndrome.