CHI3L1 and early-onset autosomal dominant Alzheimer disease: For example, two major groups of researchers, one from the Dominantly Inherited Alzheimer Network (DIAN) and the other from Alzheimer’s Disease Neuroimaging Initiative (ADNI), proposed four additional promising cerebrospinal fluid (CSF) biomarkers: chitinase-3-like protein 1 (YKL-40), neurogranin (Ng), synaptosomal-associated protein-25 (SNAP-25) and visinin-like protein 1 (VILIP-1) [14,15].