First, we assessed the systemic levels of components of the antioxidant system in peripheral blood and found that the activity of the majority of tested substances were significantly increased in patients with AMD (GPx, R-GSSG, and GSH transferase levels in RBCs and SOD, CAT, GPx, and R-GSSG levels in PLT), whereas only the CAT activity in RBC was evidently reduced in patients with AMD compared with controls. Here, SOD1 is linked to age-related macular degeneration.