This, together with the proangiogenic action of some CAF-secreted growth factors, such as vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), and platelet-derived growth factor (PDGFC), and cytokines, such as CXCL12 (also known as stromal cell-derived factor 1 or SDF-1) and CXCL14 [87], enables tumor growth and cancer cell dissemination. The gene discussed is CXCL12; the disease is neoplasm.