The roles of TLR2 during natural HSV infection are unclear, with evidence suggesting that TLR2 is important for controlling infection (Bochud et al., 2007; Sørensen et al., 2008) but also that TLR2 activation increases immunopathology in mouse models of HSV infection (Kurt-Jones et al., 2004) and pseudorabies virus infection (Laval et al., 2019). Here, TLR2 is linked to infection.