Cell cycle regulation and its upstream PI3K/AKT/GSK3β signal axis are the most distinguished drug targets in cancer therapies among which phosphorylation of GSK3β and AKT is pivotal in regulating cell growth, survival and metabolism in a variety of cells through stabilizing cell cycle regulation driver proteins (CDK2/4 and Cyclin D1/E) (Chen et al. This evidence concerns the gene CCND1 and cancer.