Compared to CC genotype, the TT and CT genotypes were associated with lymph node metastases (TT: OR=2.54, 95%CI: 1.54-4.18, P<0.001; CT: OR=2.10, 95%CI: 1.40-3.15, P<0.001), advanced stage (TT: OR=1.91, 95%CI: 1.17-3.14, P=0.010; CT: OR=1.80, 95%CI: 1.20-2.70, P=0.005), and PR positive status (TT: OR=2.02, 95%CI: 1.23-3.32, P=0.005). This evidence concerns the gene PGR and metastatic malignant neoplasm in the lymph nodes.