Vice versa, constitutive overexpression of ITGA2 in ITGA2low cancer cell line (n = 4) significantly enhanced cell adhesion to collagen I and IV (p<0.001; Figure 4C and Figure 4—figure supplement 1A–C) indicating a cell line-independent binding specificity of ITGA2 to collagen I, III, and IV. The gene discussed is ITGA2; the disease is cancer.