We believe that there is a synergistic impact of simultaneously low levels of IgGAM during sepsis, and we suggest that immunoglobulin level kinetics may be a suitable marker for monitoring and modifying treatment, although we emphasize that the required minimum levels of circulating IgM, IgG and IgA are unclear at this point and further data are required to determine the scale of changes in immunoglobulins after treatment (Table 1). Here, CD40LG is linked to Sepsis.