Ovarian cancer cells with low caspase-8 expression are resistant to apoptosis, but when the IKKβ inhibitor IV, which suppresses the NFκB pathway, is combined with the SMAC mimetic Birinapat, which inhibits cIAP, cancer cells are forced toward necroptosis in a RIPK1-dependent manner. This evidence concerns the gene NFKB1 and ovarian carcinoma.