CASP8 and melanoma: Müller et al. had investigated the nuclear expression of caspase-8 in melanoma cells and identified a hitherto unreported nuclear localization signal (NLS) (21SLKFLSLDY29) and nuclear export signal (NES) (468FTLRKKLVF476), at the N- and C-terminus of caspase-8, respectively, which enable its shuttling between the nucleus and cytosol.