The safety profile of icotinib observed in this trial was consistent with that seen previously with EGFR TKIs for the treatment of esophageal cancer.17,30 The most common radiation toxic effects were esophagitis and pneumonitis, which were similar to historical data.30 Few cases of grade 3 or 4 hematologic toxic effects were observed in our trial. The gene discussed is EGFR; the disease is pneumonitis.