Increased urinary loss of 25(OH)D may be a major cause of hypovitaminosis D in people with nephrotic syndrome both because of decreased reabsorption of 25(OH)D into the blood as well as decreased conversion of 25(OH)D to 1,25(OH)2D.46, 47, 48However, a recent report in people failed to show a difference in serum 25(OH)D and 1,25(OH)2D concentrations despite decreased urinary loss of VDBP with anti‐proteinuric treatment.44 This evidence concerns the gene GC and nephrotic syndrome.