Although mainly known as a master regulator of hematopoiesis, RUNX1 is increasingly implicated in hormone-associated epithelia including malignant conditions such as prostate cancer (Banach-Petrosky et al., 2007; Lie-A-Ling et al., 2020; Scheitz et al., 2012; Takayama et al., 2015). The gene discussed is RUNX1; the disease is Familial prostate cancer.