Mechanism researches show that the expression levels of CDHR5 could be regulated by modulating transcript expression, promoter gene methylation, etc.9, 16, 17However, our experimental results showed that the expression levels of CDHR5 showed an increasing trend during the progression of PDAC, which showed a markedly opposite change from the decreasing trend of CDHR5 expression in renal cancer and colorectal cancer. This evidence concerns the gene CDHR5 and colorectal cancer.