TRAP1 and cancer: Indeed, the primary TRAP1 function in cancer is still controversial, with the majority of authors hypothesizing an oncogenic role based on its upregulation in several human malignancies (i.e., colorectal, breast, prostate, nasopharyngeal, and lung carcinomas), whereas others suggesting an oncosuppressive function due to its downregulation in selective tumors (i.e., ovarian, renal, and cervical carcinomas) along with tumor progression [5, 9].