PTK2 and neoplasm: Our results indicate that fibroblastic FAK activity is a prognostic marker independent of all other known “classical” predictive markers (i.e. grade, tumour size, lymph nodes, resection margins, perineural and vascular invasion), and support that fibroblastic FAK activity might improve the prognostic stratification of the “differentiated‐grade” subgroup of patients for which actual histopathological markers are far to be perfect.