However, recently, a study by Colombo et al., revealed that the HABP2 p.G534E does not segregate with cancer but its mRNA had a very variable expression in tissues from FNMTC, sporadic papillary thyroid cancers (PTCs) or contralateral normal tissues opening again a question on HABP2 role in thyroid cancer [39]. This evidence concerns the gene HABP2 and familial papillary or follicular thyroid carcinoma.