AKT1 and atrial fibrillation: Considering that anticancer drugs with the strongest associations affect the phosphoinositide 3-kinase/protein kinase B (PI3K/AKT) and mitogen-activated protein kinase (MAPK) signaling pathways, the authors hypothesized these pathways as mostly implicated in AF associated with anticancer drugs, as compared with the “classical” molecular pathway of calcium-handling abnormalities [60].