MET and heart failure: Hepatocyte growth factor receptor (c-MET) inhibitors have a complex tolerability profile, with multiple mechanisms likely to result in proarrhythmia, including direct QT-prolonging effect (albeit rare), cardiac failure (rare instances especially described in the post-marketing setting), and dose-dependent symptomatic bradycardia (i.e., syncope, dizziness, and hypotension), especially with crizotinib observed in 2.4% of patients across clinical trials, and potentially developing after several weeks of drug initiation [85].