IL6 and COVID-19: In summary, the burden of arrhythmogenicity in COVID-19 can be mitigated by optimizing concomitant pharmacotherapies: in the acute viral phase, medication review and cardiovascular monitoring remain cornerstones for safe prescribing especially in patients exposed to multiple QT-prolonging drugs, including anticancer drugs, whereas in the later systemic phase, IL-6 targeted therapies (tocilizumab and sarilumab, under investigation in clinical trials) can promote the recovery from multiorgan dysfunction although the actual impact on the (high) proarrhythmic risk remains unclear.