Many studies have confirmed increased hepcidin levels in CKD patients [67–69] Serum hepcidin levels have the strongest correlation with serum ferritin, TSAT and sTfR [67, 70–72] and are influenced by inflammation [67, 72, 73] iron and ESA administration [67, 71, 72, 74] and dialysis clearance [68, 69, 75]. This evidence concerns the gene HAMP and chronic kidney disease.