Summing up, the three-drug combinations of PB + TPM + PGB, PB + OXC + TPM, PB + LTG + TPM, PB + OXC + PGB and PB + LTG + PGB, due to synergistic interactions observed in the mouse MES model, may be worthy of consideration by clinicians while treating patients with drug resistant epilepsy. This evidence concerns the gene TNFSF14 and epilepsy.