LGI1 and epilepsy: Fifth, the data do not directly determine ante hoc in an individual patient with surface antibodies when to diagnose an “epilepsy.” One may tentatively suggest to diagnose epilepsy if seizures go on for more than one year even though the antibodies in serum (LGI1 or CASPR2) or CSF (NMDAR) [27] have gone down by more than three or more than titer levels compared to onset, especially (but not necessarily), if potentially epileptogenic atrophic brain damage is evident.