The most commonly targeted antigens of NSCLC include EGFR, mesothelin (MSLN), mucin 1 (MUC1), prostate stem cell antigen (PSCA), carcinoembryonic antigen (CEA), PD-L1, CD80/CD86, inactive tyrosine-protein kinase transmembrane receptor (ROR1), and human epidermal growth factor receptor 2 (HER2). The gene discussed is CD274; the disease is non-small cell lung carcinoma.