There have been numerous studies on gene prognosis models that could contribute to the selection of LC treatment methods and the prediction of survival after LC surgery; for example, a prognostic signature containing six genes (RRAGB, RSPH9, RPS6KL1, RXFP1, RRM2, and RTL) to evaluate the prognosis of NSCLC patients (Xie & Xie, 2019). Here, RRM2 is linked to laryngotracheoesophageal cleft.