In frailer patients (G8 ≤ 14), the proportion of FOXP3+ cells was higher in the invasive front (P = 0.015) and whole tumor (P = 0.007), as compared to fit patients (G8 > 14), and the density of FOXP3+ cells was also increased in the tumor centre (P = 0.037). The gene discussed is FOXP3; the disease is neoplasm.