CD8+ TEMRA cells expressing CD27 and/or CD28 showed multiple positive correlations with tumor infiltration by CD3+, CD4+, CD5+, CD8+ and CD20+ cells, whereas senescent CD8+ TEMRA (lacking both CD27 and CD28 and/or expressing CD57) clearly exhibited a positive association with infiltration of FOXP3+ cells in the tumor. The gene discussed is CD28; the disease is neoplasm.