The density of cells staining positive for the T‐cell markers CD3 and CD5 decreased in all tumor regions with increasing age [CD3: tumor centre (P = 0.007), invasive front (P = 0.019) and whole tumor (P = 0.005); CD5: tumor centre (P = 0.022), invasive front (P = 0.006) and whole tumor (P = 0.006)] (Supplementary table 2, Figure 2). This evidence concerns the gene CD5 and neoplasm.