Thus, this galactoside-binding lectin may be added to the growing list of peptides functioning as prognostic biomarkers of heart failure (NT-proBNP, NT-proANP, MR-proANP, CT-ET-1, CT-proAVP, and MR-pro-adrenomedullin) that, in addition, negatively associate with anxiety [13–16, 51, 52]. Here, NPPB is linked to heart failure.