To address the question whether serum levels of galectin-3 are associated with anxiety, we used data from the population-based, multicenter Diagnostic Trial on Prevalence and Clinical Course of Diastolic Dysfunction and Heart Failure (Diast-CHF) study and looked for associations of the serum galectin-3 measurements with self-assessed anxiety in subjects presenting with a cardiovascular risk profile. The gene discussed is LGALS3; the disease is Anxiety.