LPAR1 and neoplasm: LPA is an important component of biofilm, an extracellular signal transmitter and intracellular second messenger, it can target endothelial differentiation gene (Edg) family LPA receptors (LPA1, LPA2, and LPA3) and non-Edg family LPA receptors (LPA4, LPA5, and LPA6) to mediate physiological and pathological processes such as angiogenesis, tumor progression, and inflammatory reactions [12].