These results emphasise the importance of TS as a prognostic and predictive marker, in line with previous literature.10 However, chemoresistance is also an important hallmark of EMT, and recent pivotal findings from our lab associated TS expression with EMT markers in cancers from different origins and suggested a potential direct role.11 To test this in NSCLC, we analysed cells belonging to the CCLE dataset and found that lung cancer cell lines with high TS expression have enrichment in EMT signature genes (Supplementary Fig. 1F, G). The gene discussed is TYMS; the disease is cancer.