In order to better understand the factors regulating how PDAC spreads to the liver, we designed an in vivo siRNA screen for suppressors of PDAC metastasis and identified inter-α-trypsin-inhibitor-5 (ITIH5) as a suppressor of PDAC metastasis; knockdown of ITIH5 was correlated with increased migration, invasion and liver metastasis.2 Much remains to be understood about the role of ITIH5 in both normal physiology and tumour biology. This evidence concerns the gene ITIH5 and neoplasm.