We previously demonstrated MSG activity of the Nme1/Nme2 locus (Fig. 1a) using the HGF mouse model of UVR-induced melanoma.6 In this study, we assessed metastasis-suppressor activities of the individual Nme1 and Nme2 genes in UVR-induced melanoma using HGF mice harbouring an additional, homozygous-null deletion of the Ink4a/p16 gene (HGF: P16−/− or “HP strain”). This evidence concerns the gene NME2 and melanoma.