It is considered to be a promising drug in treatment of autoimmune and allergic diseases.24 Recombinant CTB subunit could promote dendritic cell maturation presenting with upregulated expression of major histocompatibility complex class II and B7-2 on dendritic cell and enhanced secretion of interleukin (IL)-12 from dendritic cell, which is important for T cell stimulation and further antitumour immunity.6 Suppression of carcinogenesis in a mouse model of inflammation-driven colon cancer was observed by the oral administration of cholera toxin. This evidence concerns the gene CD86 and colonic neoplasm.