KRAS and cutaneous melanoma: Comparing the mutational landscape of brain metastases to that of cutaneous melanomas in the SKCM-TCGA dataset (see Supplementary Methods), KRAS was the most significantly enriched driver gene in our dataset, mutated in 8% (4/50) vs 2% (7/358) in the entire SCKM-TCGA collection (p = 0.0227, logistic regression Wald t test).