Multiple regression analysis using several clinical parameters at the baseline including age, eGFR, aldosterone, HDL-cholesterol, urinary NAG, urinary β2-microglobulin, α1-microglobulin, urinary albumin, and urinary protein levels demonstrated that PAC was independently associated with the rate of change in eGFR (Table 3, β = − 0.257, p = 0.0118). Here, HLA-G is linked to gonorrhea.