CD4 and cancer: “M1” high group had significantly higher rate of anti-cancer immune cell infiltration, such as CD8+ cells, CD4 memory cells, T-helper 1 (Th1) cells, natural killer (NK) cells , dendritic cells (DC) and B cells in TCGA cohort (Fig. 6A; p < 0.001, p < 0.001, p < 0.001, p < 0.01, p < 0.001, and p < 0.001 respectively).