APOE and myocardial infarction: This study aims to investigate the effects of MI-R compared to unreperfused MI on cardiac function, LV remodeling and the post-ischemic inflammatory response against the background of a hypercholesterolemic phenotype in APOE*3-Leiden mice which are known to develop advanced aortic atherosclerotic lesions resembling their human counterparts when exposed to a hypercholesterolemic phenotype as a result of a cholesterol-enriched Western-type diet27, and to test its suitability as an experimental murine MI-R model with respect to cost effectiveness and practical ease of use.