We also conducted a comprehensive computational analysis to determine the impact of the TP53 R337H variant on genomic instability, evaluating both the breast tumor tissue of the patients and homozygous (R337H+/R337H+) and heterozygous (Wt/R337H+) fibroblast cell cultures established from a patient with adrenocortical cancer and a variant carrier, respectively. The gene discussed is TP53; the disease is adrenal cortex carcinoma.