IKZF4 and neoplasm: Treg-selective deletion of essential Treg factors such as Neuropilin-1 (Nrp-1), suppressor of cytokine signaling 1 (SOCS1), enhancer of zeste homolog 2 (EZH2), Eos (IKzf4), or CARMA1 leads to Foxp3 downregulation and inflammatory cytokine secretion, conferring resistance to tumor growth in the host20–22,29–33.