The combinatory effects of HIF-2α inhibition with doxorubicin were evident in the SW1353, JJ012, and OUMS-27 chondrosarcoma cell lines (Fig. 6l), supporting the notion that HIF-2α inhibition sensitizes chondrosarcoma cells to apoptosis induced by DNA-damaging agents. This evidence concerns the gene EPAS1 and chondrosarcoma.