PIN1 and cancer: For example, small-molecule KPT-6566’s sulfanyl-acetate group attacks the sulfur atom of Pin1 Cys113 to form a disulfide bond and decrease Pin1 activity, impairing Pin1-dependent cancer phenotypes by downregulating cyclin D1.5 However, there are no reports on peptidyl covalent Pin1 inhibitors until the works of Pinch et al.