To illuminate the molecular mechanism underpinning the hyperlipidemia-ameliorating role of DNJ, we further examined the impact of DNJ on hepatic genes that are involved in lipid synthesis (SREBP1c, FAS, ACC, GPAT, SCD, ChREBP, SREBP2, and HMGR), transport (FATP, FABP, LXR, and CD36) and oxidation (CPT1, PPARα, AMPK, and ACO). The gene discussed is SREBF1; the disease is hyperlipidemia.