To illuminate the molecular mechanism underpinning the hyperlipidemia-ameliorating role of DNJ, we further examined the impact of DNJ on hepatic genes that are involved in lipid synthesis (SREBP1c, FAS, ACC, GPAT, SCD, ChREBP, SREBP2, and HMGR), transport (FATP, FABP, LXR, and CD36) and oxidation (CPT1, PPARα, AMPK, and ACO). This evidence concerns the gene KLK15 and hyperlipidemia.